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Hyaluronidase/Rituximab Injection (RITUXIMAB - SUBCUTANEOUS INJECTION)

For treating cancer.

Brand Name(s): Rituxan Hycela

Generic Name: Hyaluronidase, Human Recombinant/Rituximab

Instructions

This medicine is given as an injection into the skin.

This medicine should be given by a trained health care provider.

Drink plenty of water while on this medicine.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

Keep using this medicine for the full number of days that it is prescribed. Do not stop the medicine even if you start to feel better.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Your doctor should check you for hepatitis before you start this medicine and while you are using it. Tell your doctor if you are being treated for hepatitis or any other infection.

May cause mouth sores. Brush teeth gently. Avoid products containing alcohol. Rinse mouth with a mixture of water and baking soda or salt.

Some patients on this medicine have developed severe, life-threatening infections. Please speak with your doctor about the risks and benefits of using this medicine.

This medicine is associated with an increased risk of serious heart problems, heart attack, and stroke. Please speak with your doctor about the risks and benefits of using this medicine. Contact your doctor immediately if you experience chest pain or difficulty breathing.

This medicine is associated with a rare, but serious problem of the liver. Speak to your doctor about the early signs of liver problems and the benefits and risks of using this medicine.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

If possible, avoid using with alcohol, marijuana, or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine. You may safely start breastfeeding 6 months after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women of childbearing age should have a negative pregnancy test before starting this medicine.

Women must use reliable forms of birth control while using this medicine and for 1 year after stopping to prevent pregnancy.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • headaches
  • pain, redness, swelling near injection
  • nausea
  • weakness

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • back pain
  • loss of balance
  • bleeding or bruising
  • wheezing or difficulty breathing
  • chest pain
  • changes in memory, mood, or thinking
  • cough that does not go away
  • coughing up blood or vomit that looks like coffee grounds
  • dizziness
  • swelling of the face, mouth, tongue or throat
  • swelling of the legs, feet, and hands
  • fainting
  • fever or chills
  • numbness or tingling in hands and feet
  • severe or persistent headache
  • fast, irregular, or slow heartbeat
  • signs of kidney damage (such as change in urine color or bubbly urine)
  • signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
  • mouth sores or irritation
  • feeling of numbness or tingling, especially around the lips and mouth
  • seizures
  • red, peeling or blistering skin
  • sore throat
  • bloody or dark, tarry stools
  • symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
  • unsteadiness while walking
  • blurring or changes of vision

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.