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Binimetinib Oral Tablet (BINIMETINIB - ORAL)

For treating cancer.

Brand Name(s): Mektovi

Generic Name: Binimetinib

Instructions

This medicine may be taken with or without food.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

Please ask your doctor, nurse, or pharmacist how to discard unused medicines safely.

If you vomit after taking a dose, do not take an extra dose. Take your next dose at the usual time.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you forget to take a dose on time, take it as soon as you remember. If it is less than 6 hours to the next dose, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Your doctor may prescribe other medications to reduce side effects. Follow instructions carefully.

Keep all appointments for medical exams and tests while on this medicine.

Cautions

Avoid touching any powder from a broken tablet. If the powder touches the skin, nose, or eyes, rinse thoroughly with water.

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Do not use the medication any more than instructed.

This medicine may cause dizziness or fainting, especially after exercising or in hot weather. Be very careful when standing or sitting up quickly.

If possible, avoid using with marijuana or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

Do not breastfeed while on this medicine. You may safely start breastfeeding 3 days after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women of childbearing age should have a negative pregnancy test before starting this medicine.

To prevent pregnancy, women must use reliable forms of birth control while taking this medicine and for 30 days after stopping it.

Women who are pregnant or in their childbearing years should not touch or handle this medicine. This medicine can be absorbed through the woman's skin and harm the unborn baby.

Do not share this medicine with anyone who has not been prescribed this medicine.

Some patients have serious side effects from this medicine. Ask your pharmacist to show you the information from the Food and Drug Administration (FDA) and discuss it with you.

Always refill this medicine before it runs out.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • constipation or diarrhea
  • dizziness
  • lack of energy and tiredness
  • nausea and vomiting
  • stomach upset or abdominal pain
  • weakness
  • weight loss

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • bleeding or bruising
  • blurry vision
  • chest pain
  • coughing
  • coughing up blood or vomit that looks like coffee grounds
  • swelling of the legs, feet, and hands
  • pain in the eye
  • fainting
  • sudden leg pain, swelling, warmth or redness
  • seeing flashes or halos around lights
  • signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
  • muscle pain or weakness
  • skin changes - a darker area with uneven edges or coloring
  • skin sores
  • symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
  • blurring or changes of vision
  • vision problems - changes in seeing color

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.